toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester
CAS No.:863888-40-8
Molecular Formula:C₂₆H₃₁ClN₂O₅S
Molecular Weight:519.062
Hs Code.:

Synonyms:toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

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Chemical Property of toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

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Technology Process of toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

There total 4 articles about toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 863888-39-5
2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

: 98-59-9
p-toluenesulfonyl chloride

: 863888-40-8
toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jm701443n

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 863888-40-8
toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; triphenylphosphine; palladium diacetate / 75 °C / Inert atmosphere

2: lithium aluminium tetrahydride; sodium hydroxide / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

4: pyridine / 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium diacetate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 74248-99-0
methyl 2-(4-methoxycarbonylphenyl)ethyl ketone

: 863888-40-8
toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride; sodium hydroxide / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

3: pyridine / 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran;