74248-99-0

Basic information

• Product Name: Benzoic acid, 4-(3-oxobutyl)-, methyl ester
• CAS NO: 74248-99-0
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol File: 74248-99-0.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(3-oxobutyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(3-oxobutyl)-, methyl ester(74248-99-0)
• EPA Substance Registry System: Benzoic acid, 4-(3-oxobutyl)-, methyl ester(74248-99-0)

Safety Data

• Hazardous Substances Data: 74248-99-0(Hazardous Substances Data)

Upstream product

• 598-32-3 2-hydroxy-3-butene 
• 619-44-3 methyl 4-iodobenzoate 
• 76322-80-0 methyl 4-(3-oxobut-1-enyl)benzoate 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 78-94-4 methyl vinyl ketone 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 141-97-9 ethyl acetoacetate 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 67-56-1 methanol 
• 74248-66-1 4-(4-carboxyphenyl)butan-2-one 
• 187242-82-6 (E)-4-(3-oxobut-1-en-1-yl)benzoic acid 
• 619-66-9 4-Carboxybenzaldehyde 
• 78-93-3 butanone 
• 1184731-42-7 4-(4-(1-methoxybut-2-ynyl)phenyl)butan-2-one 

Downstream Products

• 81580-11-2 4-{3-[2-(3-Carbamoyl-4-hydroxy-phenyl)-2-hydroxy-ethylamino]-butyl}-benzoic acid methyl ester 
• 381691-39-0 methyl 4-[(4,4-dicyano-3-methylbut-3-enyl)]benzoate 
• 81580-12-3 5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride 
• 863888-49-7 4-(4-hydroxymethylphenyl)butan-2-ol 
• 74733-56-5 N-[2-(4-Carbomethoxyphenyl)-1-methylpropyl]-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine 
• 863888-39-5 2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone 
• 863888-40-8 toluene-4-sulfonic acid 3-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)-phenyl]-1-methylpropyl ester 
• 863888-41-9 2-tert-butyl-4-chloro-5-[4-(3-fluorobutyl)benzyloxy]-3-(2H)-pyridazinone 
• 120467-62-1 1,1-bis(p-methoxycarbonylphenyl)butan-3-one 
• 74248-66-1 4-(4-carboxyphenyl)butan-2-one 

Relevant articles and documents

Shuttle arylation by Rh(I) catalyzed reversible carbon–carbon bond activation of unstrained alcohols

The advent of transfer hydrogenation and borrowing hydrogen reactions paved the way to manipulate simple alcohols in previously unthinkable manners and circumvented the need for hydrogen gas. Analogously, transfer hydrocarbylation could greatly increase the versatility of tertiary alcohols. However, this reaction remains unexplored because of the challenges associated with the catalytic cleavage of unactivated C–C bonds. Herein, we report a rhodium(I)-catalyzed shuttle arylation cleaving the C(sp2)–C(sp3) bond in unstrained triaryl alcohols via a redox-neutral β-carbon elimination mechanism. A selective transfer hydrocarbylation of substituted (hetero)aryl groups from tertiary alcohols to ketones was realized, employing benign alcohols as latent C-nucleophiles. All preliminary mechanistic experiments support a reversible β-carbon elimination/migratory insertion mechanism. In a broader context, this novel reactivity offers a new platform for the manipulation of tertiary alcohols in catalysis.

Palladium-Catalyzed β-C(sp3)-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group

The direct arylation of aliphatic ketones has been developed via Pd-catalyzed β-C(sp3)-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.

BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS

The present invention relates to compounds of general formula (I), wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.