N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

Base Information

Chemical Name:N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide
CAS No.:1026309-54-5
Molecular Formula:C₂₀H₂₀N₄O₃S
Molecular Weight:396.47
Hs Code.:

Synonyms:N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

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Technology Process of N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

There total 5 articles about N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1026883-82-8
N-(2-bromo-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

: 1026309-54-5
N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

Guidance literature:: With ammonium hydroxide; copper(I) bromide; In methanol; at 110 ℃; for 12h;
DOI:10.1248/cpb.45.1027

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 1026309-54-5
N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) NaH / 1.) THF, RT, 2.) THF, reflux, 1 h

3: 50 percent / 28percent aq. NH₃, CuBr / methanol / 12 h / 110 °C

With ammonium hydroxide; sodium hydride; copper(I) bromide; In methanol;
DOI:10.1248/cpb.45.1027

Reference yield:

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 1026309-54-5
N-(2-amino-4-pyridinyl)-2-[(2,4-dimethoxybenzyl)thio]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide / toluene / 0.5 h / Heating

2: 1.) NaH / 1.) THF, RT, 2.) THF, reflux, 1 h

3: 50 percent / 28percent aq. NH₃, CuBr / methanol / 12 h / 110 °C

With Lawessons reagent; ammonium hydroxide; sodium hydride; copper(I) bromide; In methanol; toluene;
DOI:10.1248/cpb.45.1027