(S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

Base Information

• Chemical Name: (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid
• CAS No.: 142186-37-6
• Molecular Formula: C₁₃H₁₆ClNO₅
• Molecular Weight: 301.727

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

There total 4 articles about (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + L-Chp-OH → (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid (142186-37-6)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water;

DOI:10.1021/ja020237q

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-carboxy(3-chloro-4-hydroxyphenyl)methanaminium chloride → (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid (142186-37-6)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201403577

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-carboxy(3-chloro-4-hydroxyphenyl)methanaminium chloride → (2R)-2-(3-chloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid + (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid (142186-37-6)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; Overall yield = 100 %; Overall yield = 8.13 g;

upstream raw materials:

di-tert-butyl dicarbonate

(S)-hydroxyphenylglycine

Downstream raw materials:

N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 142186-37-6 (S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send