(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

Base Information

Chemical Name:(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid
CAS No.:436848-74-7
Molecular Formula:C₁₉H₃₀ClNO₅Si
Molecular Weight:415.989
Hs Code.:

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

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Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

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Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

There total 8 articles about (S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 436849-01-3
N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

: 436848-74-7
(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 24h; under 759.826 Torr;

Reference yield:

: 142186-37-6
(S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

: 436848-74-7
(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaHCO₃ / dimethylformamide / 12 h / 0 - 20 °C

2: 100 percent / tetrahydrofuran / 3 h / 40 °C

3: H₂ / Pd/C / ethanol / 1.5 h / 20 °C / 760.05 Torr

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0212314

Reference yield:

: 436849-00-2
N-tert-butoxycarbonyl-(S)-3-chloro-4-hydroxyphenylglycine benzyl ester

: 436848-74-7
(S)-2-((tert-butoxycarbonyl)amino)-2-(4-((tert-butyldimethylsilyl)oxy)-3-chlorophenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / tetrahydrofuran / 3 h / 40 °C

2: H₂ / Pd/C / ethanol / 1.5 h / 20 °C / 760.05 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/ja0212314