N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Base Information

Chemical Name:N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester
CAS No.:436849-01-3
Molecular Formula:C₂₆H₃₆ClNO₅Si
Molecular Weight:506.114
Hs Code.:

Synonyms:N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Suppliers and Price of N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

There total 7 articles about N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 77377-52-7
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

: 436849-00-2
N-tert-butoxycarbonyl-(S)-3-chloro-4-hydroxyphenylglycine benzyl ester

: 436849-01-3
N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Guidance literature:: In tetrahydrofuran; at 40 ℃; for 3h;
DOI:10.1021/ja020237q DOI:10.1021/ja0212314

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 436849-00-2
N-tert-butoxycarbonyl-(S)-3-chloro-4-hydroxyphenylglycine benzyl ester

: 436849-01-3
N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201403577

Reference yield:

: 142186-37-6
(S)-2-((tert-butoxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid

: 436849-01-3
N-tertbutoxycarbonyl-(S)-3-chloro-4-(tert-butyldimethylsilyloxy)phenylglycine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaHCO₃ / dimethylformamide / 12 h / 0 - 20 °C

2: 100 percent / tetrahydrofuran / 3 h / 40 °C

With sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0212314