5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

Base Information

Chemical Name:5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine
CAS No.:1012104-84-5
Molecular Formula:C₂₀H₃₃N₃OSi
Molecular Weight:359.587
Hs Code.:

Synonyms:5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

Chemical Property:

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Technology Process of 5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

There total 6 articles about 5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012104-48-1
(2-Amino-1-cyclohexyl-1H-benzimidazol-5-yl)methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1012104-84-5
5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 87815-77-8
4-cyclohexylamino-3-nitrobenzoic acid ethyl ester

: 1012104-84-5
5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; cyclohexene / palladium on activated carbon / ethanol / 3 h / 83 °C

2: acetonitrile; ethanol; water / 3.75 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

4: 1H-imidazole / N,N-dimethyl-formamide / 1 h

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; cyclohexene; palladium on activated carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1012104-84-5
5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / toluene / 5 h / Inert atmosphere; Reflux; Dean Stark trap

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

3: hydrogen; cyclohexene / palladium on activated carbon / ethanol / 3 h / 83 °C

4: acetonitrile; ethanol; water / 3.75 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

6: 1H-imidazole / N,N-dimethyl-formamide / 1 h

With 1H-imidazole; lithium aluminium tetrahydride; sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; cyclohexene; palladium on activated carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;