3'-METHOXY-5'-(TRIFLUOROMETHYL)ACETOPHENONE

Base Information

• Chemical Name: 3'-METHOXY-5'-(TRIFLUOROMETHYL)ACETOPHENONE
• CAS No.: 916421-06-2
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.175
• Hs Code.: 2914790090
• Mol file: 916421-06-2.mol

Synonyms:1-(3-Methoxy-5-trifluormethylphenyl)ethanone

Chemical Property of 3'-METHOXY-5'-(TRIFLUOROMETHYL)ACETOPHENONE

Chemical Property:

• Water Solubility.: Slightly soluble in water, soluble in organic solvents.

Purity/Quality:

99% ^*data from raw suppliers

3'-Methoxy-5'-(trifluoromethyl)acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3'-Methoxy-5'-(trifluoromethyl)acetophenone, is used as a Pharmaceutical, and agrochemical intermediate.

Technology Process of 3'-METHOXY-5'-(TRIFLUOROMETHYL)ACETOPHENONE

There total 3 articles about 3'-METHOXY-5'-(TRIFLUOROMETHYL)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,N-Dimethoxy-N-methyl-5-trifluoromethylbenzamide (1178585-10-8) + methylmagnesium bromide (75-16-1) → 1-(3-Methoxy-5-trifluormethylphenyl)ethanone (916421-06-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

3-hydroxy-5-(trifluoromethyl)benzoic acid (328-69-8) → 1-(3-Methoxy-5-trifluormethylphenyl)ethanone (916421-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / -15 °C / Inert atmosphere

2.2: -15 - 20 °C

3.1: diethyl ether; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With potassium carbonate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

3-methoxy-5-trifluoromethyl-benzoic acid methyl ester (1003843-90-0) → 1-(3-Methoxy-5-trifluormethylphenyl)ethanone (916421-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -15 °C / Inert atmosphere

1.2: -15 - 20 °C

2.1: diethyl ether; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

In tetrahydrofuran; diethyl ether;

upstream raw materials:

3,N-Dimethoxy-N-methyl-5-trifluoromethylbenzamide

methylmagnesium bromide

3-hydroxy-5-(trifluoromethyl)benzoic acid

3-methoxy-5-trifluoromethyl-benzoic acid methyl ester

Downstream raw materials:

2-bromo-1-[3-methoxy-5-(trifluoromethyl)phenyl]ethanone

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