(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate
CAS No.:1026789-62-7
Molecular Formula:C₂₅H₂₅N₇O₃
Molecular Weight:471.519
Hs Code.:

Synonyms:(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

There total 10 articles about (R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911825-77-9
(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

: 1026789-62-7
(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Guidance literature:: With sodium dithionite; sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 40154-75-4
(R)-1-(pyridin-3-yl)ethan-1-amine

: 1026789-62-7
(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / tetrahydrofuran / 21.5 h / 0 - 20 °C

2: tetrahydrofuran / 4 h / 50 °C

3: dmap / dichloromethane / 16 h

4: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran; methanol / 0.5 h

5: tetrahydrofuran / 20 h / 50 °C

6: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

7: potassium carbonate / acetonitrile / 2 h

8: sodium hydride / N,N-dimethyl-formamide / 4 h / -25 - -15 °C

9: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran

With triethylsilane; dmap; sodium dithionite; water; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1083301-53-4
C₁₂H₁₁ClN₄O₂

: 1026789-62-7
(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 4 h / 50 °C

2: dmap / dichloromethane / 16 h

3: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran; methanol / 0.5 h

4: tetrahydrofuran / 20 h / 50 °C

5: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

6: potassium carbonate / acetonitrile / 2 h

7: sodium hydride / N,N-dimethyl-formamide / 4 h / -25 - -15 °C

8: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran

With triethylsilane; dmap; sodium dithionite; water; sodium hydride; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;