(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate
CAS No.:911825-77-9
Molecular Formula:C₂₅H₂₃N₇O₅
Molecular Weight:501.502
Hs Code.:

Synonyms:(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

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Chemical Property of (R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

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Technology Process of (R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

There total 9 articles about (R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218632-01-0
3-fluoro-4-nitrobenzonitrile

: 911825-76-8
(R)-tert-butyl 5-amino-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

: 911825-77-9
(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Guidance literature:: 3-fluoro-4-nitrobenzonitrile; (R)-tert-butyl 5-amino-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at -25 - -15 ℃; for 4h;

With ammonium chloride; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 40154-75-4
(R)-1-(pyridin-3-yl)ethan-1-amine

: 911825-77-9
(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / tetrahydrofuran / 21.5 h / 0 - 20 °C

2: tetrahydrofuran / 4 h / 50 °C

3: dmap / dichloromethane / 16 h

4: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran; methanol / 0.5 h

5: tetrahydrofuran / 20 h / 50 °C

6: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

7: potassium carbonate / acetonitrile / 2 h

8: sodium hydride / N,N-dimethyl-formamide / 4 h / -25 - -15 °C

With triethylsilane; dmap; sodium dithionite; water; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1083301-53-4
C₁₂H₁₁ClN₄O₂

: 911825-77-9
(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 4 h / 50 °C

2: dmap / dichloromethane / 16 h

3: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran; methanol / 0.5 h

4: tetrahydrofuran / 20 h / 50 °C

5: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

6: potassium carbonate / acetonitrile / 2 h

7: sodium hydride / N,N-dimethyl-formamide / 4 h / -25 - -15 °C

With triethylsilane; dmap; sodium dithionite; water; sodium hydride; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;