(R)-1-Pyridin-3-yl-ethylaMine 2HCl

Base Information

• Chemical Name: (R)-1-Pyridin-3-yl-ethylaMine 2HCl
• CAS No.: 40154-75-4
• Molecular Formula: C7H12Cl2N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• Mol file: 40154-75-4.mol

Synonyms:(R)-1-Pyridin-3-yl-ethylaMine 2HCl;(R)-1-Pyridin-3-yl-ethylamine;(R)-1-(pyridin-3-yl)ethanamine;(1R)-1-(PYRIDIN-3-YL)ETHAN-1-AMINE DIHYDROCHLORIDE

Chemical Property of (R)-1-Pyridin-3-yl-ethylaMine 2HCl

Chemical Property:

• Boiling Point: 221.0±15.0 °C(Predicted)
• PKA: 8.81±0.29(Predicted)
• PSA: 38.91000
• Density: 1.018±0.06 g/cm3(Predicted)
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-(Pyridin-3-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-Pyridin-3-yl-ethylaMine 2HCl

There total 6 articles about (R)-1-Pyridin-3-yl-ethylaMine 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-pyridin-3-yl-ethylamine (56129-55-6) → (R)-1-(pyridin-3-yl)ethan-1-amine (40154-75-4) + methyl-3-pyridylketone (350-03-8)

Guidance literature:

With L-amino acid oxidase; ATA-113; pyridoxal 5'-phosphate; 2-oxo-propionic acid; at 30 ℃; for 3h; pH=8; optical yield given as %ee; enantioselective reaction; Resolution of racemate; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/b902995h

Reference yield:

(R)-2-methyl-N-(1-(pyridin-3-yl)ethyl)propane-2-sulfinamide (1013624-59-3) → (R)-1-(pyridin-3-yl)ethan-1-amine (40154-75-4) + (1S)-1-(pyridin-3-yl)ethan-1-amine (27854-93-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03603

Reference yield:

(RS)-N-[1-(pyridin-3-yl)ethylidene]-2-methylpropane-2-sulfinamide (926921-86-0) → (R)-1-(pyridin-3-yl)ethan-1-amine (40154-75-4) + (1S)-1-(pyridin-3-yl)ethan-1-amine (27854-93-9)

Guidance literature:

(R_S)-N-[1-(pyridin-3-yl)ethylidene]-2-methylpropane-2-sulfinamide; With L-Selectride; In tetrahydrofuran; at -78 ℃; for 6h;

With hydrogenchloride; In methanol; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2006.11.026

upstream raw materials:

(R_S)-N-[1-(pyridin-3-yl)ethylidene]-2-methylpropane-2-sulfinamide

(R_S,R)-N-[1-(pyridin-3-yl)ethyl]-2-methylpropane-2-sulfinamide

methyl-3-pyridylketone

1-pyridin-3-yl-ethylamine

Downstream raw materials:

(R)-tert-butyl 5-(5-cyano-2-nitrophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

(R)-tert-butyl 5-(2-amino-5-cyanophenylamino)-2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydroimidazo[4,5-b]pyridine-1-carboxylate

(R)-tert-butyl 2,4-dimethoxybenzyl-(2-oxo-3-(1-(pyridin-3-yl)ethyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)carbamate

(R)-tert-butyl 2,4-dimethoxybenzyl-(5-nitro-6-(1-(pyridin-3-yl)ethylamino)pyridin-2-yl)carbamate