Technology Process of methyl 3-(benzyloxy)-13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate
There total 6 articles about methyl 3-(benzyloxy)-13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 5-amino-1H-pyrazole-3-carboxylate hydrochloride;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
1-[4-(benzyloxy)-2-(2-chloroethoxy)phenyl]-2-bromo-2-cyclohexylethanone;
In
N,N-dimethyl-formamide; mineral oil;
at 20 - 100 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bromine / 1,4-dioxane; diethyl ether / 0.33 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
2.2: 18 h / 20 - 100 °C
With
bromine; sodium hydride;
In
1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / 20 °C / Inert atmosphere
2.1: potassium carbonate / acetonitrile / 17 h / 20 °C / Inert atmosphere
3.1: tetrabutylammomium bromide; sodium hydroxide / water; 1,2-dichloro-ethane / 49.5 h / Reflux
4.1: bromine / 1,4-dioxane; diethyl ether / 0.33 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
5.2: 18 h / 20 - 100 °C
With
boron trifluoride diethyl etherate; tetrabutylammomium bromide; bromine; sodium hydride; potassium carbonate; sodium hydroxide;
In
1,4-dioxane; diethyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
