methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

Base Information

Chemical Name:methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate
CAS No.:1427550-10-4
Molecular Formula:C₂₁H₂₃N₃O₄
Molecular Weight:381.431
Hs Code.:

Synonyms:methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

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Chemical Property of methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

There total 7 articles about methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1427550-09-1
methyl 3-(benzyloxy)-13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

: 1427550-10-4
methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 1.08333h;

Reference yield:

: 1427550-07-9
1-[4-(benzyloxy)-2-(2-chloroethoxy)phenyl]-2-cyclohexylethanone

: 1427550-10-4
methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / 1,4-dioxane; diethyl ether / 0.33 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 - 100 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 1.08 h

With palladium 10% on activated carbon; hydrogen; bromine; sodium hydride; In 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 108-46-3
recorcinol

: 1427550-10-4
methyl 13-cyclohexyl-3-hydroxy-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / 20 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 17 h / 20 °C / Inert atmosphere

3.1: tetrabutylammomium bromide; sodium hydroxide / water; 1,2-dichloro-ethane / 49.5 h / Reflux

4.1: bromine / 1,4-dioxane; diethyl ether / 0.33 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

5.2: 18 h / 20 - 100 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 1.08 h

With palladium 10% on activated carbon; boron trifluoride diethyl etherate; tetrabutylammomium bromide; hydrogen; bromine; sodium hydride; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; diethyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;