(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

Base Information

Chemical Name:(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane
CAS No.:705947-64-4
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

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Chemical Property of (2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

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Technology Process of (2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

There total 2 articles about (2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 5532-86-5
benzyl cyanoformate

: 705947-38-2
(2R,5S)-1-aza-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

: 705947-64-4
(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

: (+)-(2R,5S)-1-aza-8-dibenzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

Guidance literature:: (2R,5S)-1-aza-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane; With sec.-butyllithium; In tetrahydrofuran; at -78 - -30 ℃;

benzyl cyanoformate; In tetrahydrofuran; at -78 ℃;
DOI:10.1039/b316037h

Reference yield: 46.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 705947-38-2
(2R,5S)-1-aza-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

: 705947-64-4
(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

: (+)-(2R,5S)-1-aza-8-dibenzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

Guidance literature:: (2R,5S)-1-aza-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane; With sec.-butyllithium; In tetrahydrofuran; at -78 - -30 ℃;

benzyl chloroformate; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1039/b316037h

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 705947-64-4
(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane

: (+)-(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenyl-8-phenylselenylbicyclo[4.3.0]nonane

: (-)-(2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenyl-8-phenylselenylbicyclo[4.3.0]nonane

Guidance literature:: (2R,5S)-1-aza-8-benzyloxycarbonyl-2-methyl-3-oxa-9-oxo-2-phenylbicyclo[4.3.0]nonane; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

Phenylselenyl chloride; In tetrahydrofuran; at 25 ℃; for 5h; Further stages.;
DOI:10.1039/b316037h