4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

Base Information

Chemical Name:4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile
CAS No.:926888-88-2
Molecular Formula:C₂₈H₃₀N₄
Molecular Weight:422.573
Hs Code.:

Synonyms:4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

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Chemical Property of 4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

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Technology Process of 4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

There total 3 articles about 4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₈N₃BO₂

: 623-00-7
4-bromobenzenecarbonitrile

: 926888-88-2
4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; at 90 ℃; for 0.5h; microwave irradiation;
DOI:10.1021/jo0622072

Reference yield:

: 14542-93-9
1,1,3,3-tetramethylbutane isonitrile

: 926888-88-2
4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: MgCl₂ / methanol / 0.17 h / 160 °C / microwave irradiation

2: 0.160 g / aq. K₂CO₃ / Pd(dppf)Cl₂ / methanol / 0.5 h / 90 °C / microwave irradiation

With potassium carbonate; magnesium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1: Ugi cyclization / 2: Suzuki coupling;
DOI:10.1021/jo0622072

Reference yield:

: 100-52-7
benzaldehyde

: 926888-88-2
4-(2-phenyl-3-(2,4,4-trimethylpentan-2-ylamino)-imidazo[1,2-a]pyridin-6-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: MgCl₂ / methanol / 0.17 h / 160 °C / microwave irradiation

2: 0.160 g / aq. K₂CO₃ / Pd(dppf)Cl₂ / methanol / 0.5 h / 90 °C / microwave irradiation

With potassium carbonate; magnesium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1: Ugi cyclization / 2: Suzuki coupling;
DOI:10.1021/jo0622072