1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide
CAS No.:1379600-87-9
Molecular Formula:C₂₅H₂₁F₃N₄O
Molecular Weight:450.463
Hs Code.:

Synonyms:1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

There total 7 articles about 1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1379600-86-8
N-ethyl-1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

: 1379600-87-9
1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 3620.13 Torr;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1379600-87-9
1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 2 h / 60 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran

3: toluene-4-sulfonic acid / ethanol / Microwave irradiation

4: ethanol / 120 °C / Sealed tube

5: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 3620.13 Torr

With palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; palladium diacetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate;
DOI:10.1021/jm2007744

Reference yield:

: 142557-76-4
4-acetyl-4'-trifluoromethylbiphenyl

: 1379600-87-9
1-(4-aminophenyl)-N-ethyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran

2: toluene-4-sulfonic acid / ethanol / Microwave irradiation

3: ethanol / 120 °C / Sealed tube

4: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 3620.13 Torr

With palladium on activated charcoal; hydrogen; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; ethyl acetate;
DOI:10.1021/jm2007744