ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate
CAS No.:1379600-85-7
Molecular Formula:C₂₅H₁₈F₃N₃O₄
Molecular Weight:481.431
Hs Code.:

Synonyms:ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

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Chemical Property of ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

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Technology Process of ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

There total 5 articles about ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-nitrophenyl)hydrazine hydrochloride

: 1379600-88-0
(Z)-ethyl 2-hydroxy-4-oxo-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)but-2-enoate

: 1379600-85-7
ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

Guidance literature:: In ethanol; at 20 ℃; for 16h;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1379600-85-7
ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 2 h / 60 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran

3: toluene-4-sulfonic acid / ethanol / Microwave irradiation

With tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm2007744

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1379600-85-7
ethyl 1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 2 h / 60 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran

3: toluene-4-sulfonic acid / ethanol / Microwave irradiation

With tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm2007744