bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester

Base Information

• Chemical Name: bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester
• CAS No.: 1333113-80-6
• Molecular Formula: C₄₃H₅₃N₃O₈
• Molecular Weight: 739.909
• Mol file: 1333113-80-6.mol

Synonyms:bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester

Chemical Property of bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester

There total 1 articles about bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-((tert-butyloxy)carbonyl)iminodiacetic acid (56074-20-5) + 1,3-bis(benzyloxy)propan-2-amine (132819-08-0) → bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester (1333113-80-6)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 9.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.064

Reference yield:

bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester (1333113-80-6) → C38H45N3O6 (1333113-87-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 30h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.064

Reference yield:

bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester (1333113-80-6) → C57H71N5O9 (1333113-89-5)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 30 h / 20 °C / Inert atmosphere

2: pyridine / 15 h / 100 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

4: triethylamine / tetrahydrofuran / 40 h / 20 °C / Inert atmosphere

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.064

upstream raw materials:

N-((tert-butyloxy)carbonyl)iminodiacetic acid

1,3-bis(benzyloxy)propan-2-amine

Downstream raw materials:

C₃₈H₄₅N₃O₆

C₅₇H₇₁N₅O₉

N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

N-(8-benzoylaminooctyl)-N,N-bis-[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamide