N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

Base Information

Chemical Name:N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester
CAS No.:1333113-81-7
Molecular Formula:C₄₆H₅₂N₄O₁₁
Molecular Weight:836.939
Hs Code.:

Synonyms:N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

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Chemical Property of N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

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Technology Process of N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

There total 4 articles about N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1333113-88-4
C₄₂H₄₉N₃O₉

: 1333113-81-7
N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; for 18h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.06.064

Reference yield:

: 1333113-87-3
C₃₈H₄₅N₃O₆

: 1333113-81-7
N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 15 h / 100 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.06.064

Reference yield:

: 1333113-80-6
bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]carbamic acid tert-butyl ester

: 1333113-81-7
N,N-bis[(2-benzyloxy-1-benzyloxymethylethylcarbamoyl)methyl]succinamic acid 2,5-dioxopyrrlidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 30 h / 20 °C / Inert atmosphere

2: pyridine / 15 h / 100 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.064