ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

Base Information

Chemical Name:ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate
CAS No.:1354728-62-3
Molecular Formula:C₂₀H₁₇ClO₆S
Molecular Weight:420.87
Hs Code.:

Synonyms:ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

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Chemical Property of ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

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Technology Process of ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

There total 4 articles about ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1354728-91-8
4-chloro-2-ethynylphenyl acetate

: 134919-31-6
ethyl α-diazo-α-phenylsulfonylacetate

: 1354728-62-3
ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

Guidance literature:: With dirhodium tetraacetate; In dichloromethane; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/ol2032009

Reference yield:

: 71643-66-8
4-chloro-2-iodo phenol

: 1354728-62-3
ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 11 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 3 h / 20 °C

3: potassium fluoride dihydrate / N,N-dimethyl-formamide / 4 h / 20 °C

4: dirhodium tetraacetate / dichloromethane / 2 h / Inert atmosphere; Reflux

With dmap; bis-triphenylphosphine-palladium(II) chloride; dirhodium tetraacetate; copper(l) iodide; potassium fluoride dihydrate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol2032009

Reference yield:

: 183589-01-7
4-chloro-2-iodophenyl acetate

: 1354728-62-3
ethyl 2-(2-acetoxy-5-chlorophenyl)-1-(phenylsulfonyl)cycloprop-2-enecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 3 h / 20 °C

2: potassium fluoride dihydrate / N,N-dimethyl-formamide / 4 h / 20 °C

3: dirhodium tetraacetate / dichloromethane / 2 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; dirhodium tetraacetate; copper(l) iodide; potassium fluoride dihydrate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol2032009