N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

Base Information

Chemical Name:N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride
CAS No.:1346461-01-5
Molecular Formula:C₁₁H₁₅Cl₂NO*ClH
Molecular Weight:284.613
Hs Code.:

Synonyms:N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

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Technology Process of N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

There total 4 articles about N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

: 50516-63-7
1-(3,4-dichlorophenyl)-3-(dimethylamino)-1-propanone

: 1346461-01-5
N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

Guidance literature:: 1-(3,4-dichlorophenyl)-3-(dimethylamino)-1-propanone; With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.08.045

Reference yield: 93.6%

: 1346461-01-5
N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: 35857-66-0
3-chloro-1-(3,4-dichlorophenyl)propan-1-one

: 1346461-01-5
N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

1.2: 1 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2.2: 1 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2014.08.045