50516-63-7

Upstream product

• 35857-66-0 3-chloro-1-(3,4-dichlorophenyl)propan-1-one 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 95-50-1 1,2-dichloro-benzene 
• 1826-67-1 vinyl magnesium bromide 
• 200802-01-3 3,4‐dichloro‐N‐methoxy‐N‐methylbenzamide 
• 50-00-0 formaldehyd 
• 2642-63-9 3',4'-dichloroacetophenone 
• 75144-12-6 1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrochloride 
• 87142-63-0 1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrobromide 

Downstream Products

• 161229-01-2 (R)-1-(3,4-Dichloro-phenyl)-3-dimethylamino-propan-1-ol 
• 161229-01-2 (S)-1-(3,4-Dichloro-phenyl)-3-dimethylamino-propan-1-ol 
• 1225932-01-3 3-(dimethylamino)-1-(3,4-dichlorobenzene)-1-propanol 
• 1236376-40-1 3-(3,4-dichlorophenyl)-6,7-dimethyl-3-(2-dimethylaminoethyl)isochroman-1-one 
• 1346461-01-5 N,N-dimethyl-3-(3,4-dichlorophenyl)-3-hydroxy-propylamine hydrochloride 
• 1198348-59-2 (S)-[3-(3,4-dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine 
• 1198348-57-0 [3-(3,4-dichloro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine 
• 1198348-58-1 [3-(3,4-dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine 
• 746544-64-9 3-(3,4-dichlorophenyl)-3-(2-dimethylaminoethyl)isochroman-1-one 

Relevant academic research and scientific papers

3-[(BENZO[D][1,3]DIOXOLAN-4-YL)-OXY]-3-ARYLPROPYLAMINE TYPE COMPOUNDS AND APPLICATIONS THEREOF

The present invention relates to 3-[(benzo[d][1,3]dioxolan-4-yl)-oxy]-3-arylpropylamine compounds of formula I or pharmaceutically acceptable salts thereof and use thereof. The compound may be used to prepare an antidepressant agent.

PYRIDINE DERIVATIVES AND APPLICATION OF ANTI-MACOBACTERIUM THEREOF

The present invention provides a series of pyridine derivatives and their preparation method and application thereof. The series of pyridine derivatives can be applied to treating mycobacterium-related diseases, especially to treatments of fatal mycobacterium-related diseases. The fatal diseases may be related to mycobacterium tuberculosis, mycobacterium bovis, mycobacterium avium, and mycobacterium marinum.

Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors

A series of aralkyl diamine derivatives were designed, synthesized, and evaluated for their triple reuptake inhibitory abilities. Compounds 18c (5-HT, NE, DA, IC50 = 389, 69, 238 nM), 36a (5-HT, NE, DA, IC50 = 378, 477, 247 nM), and

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.

Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors

A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In

Optimization of isochromanone based urotensin II receptor agonists

A series of novel isochromanone based urotensin II receptor agonists have been synthesized and evaluated for their activity using a functional cell based assay (R-SAT). Several potent and efficacious derivatives were identified with 3-(3,4-dichlorophenyl)-6,7-dimethyl-3-(2-dimethylaminoethyl)isochroman-1-one (28) being the most potent compound showing an EC50-value of 51 nM, thereby being the most potent compound so far within the isochromanone series. In addition, two other heterocyclic systems (isochromanes and tetrahydroisoquinolinones) were investigated and these derivatives were found to be both potent and efficacious. The activity of the isochromane derivatives implies that the carbonyl group of the isochromanone is not necessary for activity. Furthermore it was found that the geometry of the heterocycles was more important for receptor interaction than the composition of the heteroatoms present.

3-Substituted Propanamine Compounds

Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are als

3-SUBSTITUTED PROPANAMINE COMPOUNDS

Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I) or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also

Evaluation of some Mannich bases derived from substituted acetophenones against P-388 lymphocytic leukemia and on respiration in isolated rat liver mitochondria

Series of 3-dimethylamino-1-aryl-1-propanone hydrobromides (IV) and 3-dimethylamino-2-dimethylaminomethyl-1-aryl-1-propanone dihydrobromides (V) were synthesized. Evaluation of these derivatives against P-388 lymphocytic leukemia growth revealed that two compounds show promise as antineoplastic agents. Compounds of the V series were unstable in phosphate buffer (in contrast to series IV), and when the same nuclear substituent was present in both series of compounds, V was ~ 100 times more active than IV in both the stimulation and inhibition of respiration of mitochondria isolated from rat liver cells. Representatives from both series showed that respiration in mitochondria was affected by changing the pH of the aqueous buffer from 7.4 to 6.9 or 6.4 and by reducing the temperature from 37° to 20°. The compounds showed reactivity toward a biomimetic thiol.