9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

Base Information

Chemical Name:9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide
CAS No.:287409-51-2
Molecular Formula:C₂₆H₃₁N₃O₅S₂
Molecular Weight:529.681
Hs Code.:

Synonyms:9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

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Chemical Property of 9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

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Technology Process of 9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

There total 3 articles about 9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: methyl (3S)-4-{[4-(2-butynyloxy)phenyl]sulfonyl}-2,2,6-trimethyl-3-thiomorpholinecarboxylate

: 287409-51-2
9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

Guidance literature:: methyl (3S)-4-{[4-(2-butynyloxy)phenyl]sulfonyl}-2,2,6-trimethyl-3-thiomorpholinecarboxylate; With sodium hydroxide; water; In tetrahydrofuran; methanol; for 6h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=3 - 4;

Reference yield:

: C₂₆H₂₉ClN₂O₄S₂

: 287409-51-2
9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); acetonitrile; at 20 ℃; for 1h;

C₂₆H₂₉ClN₂O₄S₂; In DMF (N,N-dimethyl-formamide); dichloromethane; acetonitrile; at 20 ℃; for 6h;

Reference yield:

: 79-37-8
oxalyl dichloride

: 287408-08-6
9-benzyl-4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-thia-4,9-diazaspiro[5.5]-undecane-5-carboxylic acid

: 9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide hydrochloride

: 287409-51-2
9-benzyl-4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-N-hydroxy-1-thia-4,9-diazaspiro[5.5]undecane-5-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In methanolic hydrochloric acid; dichloromethane; N,N-dimethyl-formamide; acetonitrile;