N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

Base Information

Chemical Name:N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane
CAS No.:152623-98-8
Molecular Formula:C₁₄H₁₅ClF₃NO₃
Molecular Weight:337.726
Hs Code.:

Synonyms:N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

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Chemical Property of N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

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Technology Process of N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

There total 2 articles about N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-04-9
chloroacetyl chloride

: 152623-97-7
N-(trifluoroacetyl)-1-(3-methoxyphenyl)-2-aminopropane

: 152623-98-8
N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

Guidance literature:: With aluminium trichloride; In 1,2-dichloro-ethane; at 45 ℃; for 4h;
DOI:10.1021/jm00075a027

Reference yield:

: 17862-85-0
3-methoxyamphetamine

: 152623-98-8
N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N / 1.) CH₂Cl₂, 10 min, 2.) CH₂Cl₂, RT, 1.5 h

2: 3.5 g / AlCl₃ / 1,2-dichloro-ethane / 4 h / 45 °C

With aluminium trichloride; triethylamine; In 1,2-dichloro-ethane;
DOI:10.1021/jm00075a027

Reference yield:

: 152623-98-8
N-(trifluoroacetyl)-1-<3-methoxy-4-(chloroacetyl)phenyl>-2-aminopropane

: 152623-93-3
6-(2-aminopropyl)-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BBr₃, 2.) NaOAc / 1.) CH₂Cl₂, -78 deg C to RT, 12 h, 2.) CH₃OH, reflux, 1.5 h

2: H₂ / 20percent PdOH/C / ethanol / 12 h / 2689.2 Torr

3: 2N KOH / propan-2-ol / 5 h / Heating

With potassium hydroxide; hydrogen; sodium acetate; boron tribromide; PdOH/C; In ethanol; isopropyl alcohol;
DOI:10.1021/jm00075a027