ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Base Information

Chemical Name:ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate
CAS No.:1402054-40-3
Molecular Formula:C₂₆H₃₃N₉O₆
Molecular Weight:567.605
Hs Code.:

Synonyms:ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

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Chemical Property of ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

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Technology Process of ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

There total 11 articles about ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82977-45-5
tetrahydro-5-oxofuran-2-carboxylic acid chloride

: ethyl 2-(4-(4-(2-(6-amino-4-hydrazinyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate trihydrochloride

: 1402054-40-3
ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.666667h; Cooling with ice;

Reference yield:

: 4344-84-7,21461-84-7,53558-93-3,83829-70-3
5-oxo-tetrahydro-furan-2-carboxylic acid

: 1402054-40-3
ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Cooling with ice

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 158985-25-2
tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

: 1402054-40-3
ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 120 h / 20 - 100 °C / Inert atmosphere; Sealed tube

4: hydrogenchloride / dichloromethane; 1,4-dioxane; ethanol / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Cooling with ice

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;