ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Base Information

Chemical Name:ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate
CAS No.:1402054-41-4
Molecular Formula:C₂₆H₃₁N₉O₅
Molecular Weight:549.589
Hs Code.:

Synonyms:ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

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Chemical Property of ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

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Technology Process of ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

There total 10 articles about ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1402054-40-3
ethyl 2-(4-(4-(2-(6-amino-4-(2-(5-oxotetrahydrofuran-2-carbonyl)hydrazinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)piperazin-1-yl)phenoxy)acetate

: 1402054-41-4
ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; at 20 - 100 ℃; for 22.5h; Inert atmosphere; Sealed tube;

Reference yield:

: 158985-25-2
tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

: 1402054-41-4
ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 120 h / 20 - 100 °C / Inert atmosphere; Sealed tube

4: hydrogenchloride / dichloromethane; 1,4-dioxane; ethanol / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Cooling with ice

6: N,O-bis-(trimethylsilyl)-acetamide / 22.5 h / 20 - 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; N,O-bis-(trimethylsilyl)-acetamide; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5604-46-6
2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

: 1402054-41-4
ethyl 2-(4-(4-(2-(5-amino-2-(5-oxotetrahydrofuran-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrazine hydrate / water; tetrahydrofuran / 50 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3: N,N-dimethyl-formamide / 48 h / 20 - 80 °C

4: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 120 h / 20 - 100 °C / Inert atmosphere; Sealed tube

5: hydrogenchloride / dichloromethane; 1,4-dioxane; ethanol / 3 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Cooling with ice

7: N,O-bis-(trimethylsilyl)-acetamide / 22.5 h / 20 - 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; N,O-bis-(trimethylsilyl)-acetamide; hydrazine hydrate; sodium hydride; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;