diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

Base Information

Chemical Name:diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate
CAS No.:132261-14-4
Molecular Formula:C₃₁H₂₈N₄O₆S
Molecular Weight:584.653
Hs Code.:

Synonyms:diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

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Chemical Property of diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

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Technology Process of diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

There total 3 articles about diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 67-56-1
methanol

: 132261-13-3
(6R,7S)-3-Acetoxymethyl-7-(1H-benzoimidazol-2-ylamino)-7-methylsulfanyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 132261-14-4
diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

Guidance literature:: With pyridine; mercury dichloride; In dichloromethane; N,N-dimethyl-formamide; at -15 - 0 ℃;
DOI:10.1021/jm00107a035

Reference yield:

: 52403-62-0
diphenylmethyl (6R,7R)-3-acetoxymethyl-7-isocyanoceph-3-em-4-carboxylate

: 132261-14-4
diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / Cu₂O / tetrahydrofuran / 3.5 h / 45 °C

2: Br₂ / toluene; CCl₄ / -78 - 20 °C

3: tetrahydrofuran / Ambient temperature

4: 78 percent / pyridine, HgCl₂ / dimethylformamide; CH₂Cl₂ / -15 - 0 °C

With pyridine; copper(I) oxide; bromine; mercury dichloride; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00107a035

Reference yield:

: 132261-22-4
C₂₅H₂₂N₂O₅S₂

: 132261-14-4
diphenylmethyl 3-(acetoxymethyl)-7-(benzimidazol-2-ylamino)-7-methoxyceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / toluene; CCl₄ / -78 - 20 °C

2: tetrahydrofuran / Ambient temperature

3: 78 percent / pyridine, HgCl₂ / dimethylformamide; CH₂Cl₂ / -15 - 0 °C

With pyridine; bromine; mercury dichloride; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00107a035