tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

Base Information

Chemical Name:tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester
CAS No.:608136-32-9
Molecular Formula:C₁₉H₂₆N₂O₆
Molecular Weight:378.425
Hs Code.:

tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-<i>tert</i>-butyl ester 3-methyl ester

Synonyms:tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

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Chemical Property of tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

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Technology Process of tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

There total 10 articles about tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 608136-22-7
(R)-2-acetoxy-5-benzyloxy-1-(tert-butyldimethylsilyloxy)pentane

: 608136-32-9
tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 0.5 h / 20 °C / 760 Torr

2.1: 100 percent / Dess-Martin periodinane / CHCl₃ / 0 - 20 °C

3.1: methanol / 0 - 20 °C

3.2: 67 percent / acetic acid; sodium cyanoborohydride / methanol / 0 - 20 °C

4.1: 97 percent / aqueous sodium bicarbonate / CHCl₃ / 1.5 h / 0 °C

5.1: 73 percent / H₂O; K₂CO₃ / methanol / 6 h / 20 °C

6.1: 86 percent / PPh₃; EtOOCN=NCOOEt / tetrahydrofuran / 0.5 h / Heating

7.1: 100 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

8.1: CrO₃; sulfuric acid / acetone; H₂O / 1 h / 20 °C

9.1: 0.13 g / methanol; hexane / 20 °C

With chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; chloroform; water; acetone; 2.1: Dess-Martin oxidation / 6.1: Mitsunobu reaction / 8.1: Jones oxidation;
DOI:10.1021/jo034441n

Reference yield:

: 608136-27-2
acetic acid 1-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-butyl ester

: 608136-32-9
tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 0 - 20 °C

1.2: 67 percent / acetic acid; sodium cyanoborohydride / methanol / 0 - 20 °C

2.1: 97 percent / aqueous sodium bicarbonate / CHCl₃ / 1.5 h / 0 °C

3.1: 73 percent / H₂O; K₂CO₃ / methanol / 6 h / 20 °C

4.1: 86 percent / PPh₃; EtOOCN=NCOOEt / tetrahydrofuran / 0.5 h / Heating

5.1: 100 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

6.1: CrO₃; sulfuric acid / acetone; H₂O / 1 h / 20 °C

7.1: 0.13 g / methanol; hexane / 20 °C

With chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; chloroform; water; acetone; 4.1: Mitsunobu reaction / 6.1: Jones oxidation;
DOI:10.1021/jo034441n

Reference yield:

: 608136-26-1
acetic acid 1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-butyl ester

: 608136-32-9
tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / Dess-Martin periodinane / CHCl₃ / 0 - 20 °C

2.1: methanol / 0 - 20 °C

2.2: 67 percent / acetic acid; sodium cyanoborohydride / methanol / 0 - 20 °C

3.1: 97 percent / aqueous sodium bicarbonate / CHCl₃ / 1.5 h / 0 °C

4.1: 73 percent / H₂O; K₂CO₃ / methanol / 6 h / 20 °C

5.1: 86 percent / PPh₃; EtOOCN=NCOOEt / tetrahydrofuran / 0.5 h / Heating

6.1: 100 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

7.1: CrO₃; sulfuric acid / acetone; H₂O / 1 h / 20 °C

8.1: 0.13 g / methanol; hexane / 20 °C

With chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; chloroform; water; acetone; 1.1: Dess-Martin oxidation / 5.1: Mitsunobu reaction / 7.1: Jones oxidation;
DOI:10.1021/jo034441n