Technology Process of 1,3(2H)-Pyridazinedicarboxylic acid, tetrahydro-, 3-methyl
1-(phenylmethyl) ester, (S)-
There total 14 articles about 1,3(2H)-Pyridazinedicarboxylic acid, tetrahydro-, 3-methyl
1-(phenylmethyl) ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride;
at 0 - 20 ℃;
for 1h;
Heating / reflux;
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 3h;
DOI:10.1021/jo034441n
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 99 percent / H2 / Pd/C / methanol / 0.5 h / 20 °C / 760 Torr
2.1: 100 percent / Dess-Martin periodinane / CHCl3 / 0 - 20 °C
3.1: methanol / 0 - 20 °C
3.2: 67 percent / acetic acid; sodium cyanoborohydride / methanol / 0 - 20 °C
4.1: 97 percent / aqueous sodium bicarbonate / CHCl3 / 1.5 h / 0 °C
5.1: 73 percent / H2O; K2CO3 / methanol / 6 h / 20 °C
6.1: 86 percent / PPh3; EtOOCN=NCOOEt / tetrahydrofuran / 0.5 h / Heating
7.1: 100 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C
8.1: CrO3; sulfuric acid / acetone; H2O / 1 h / 20 °C
9.1: 0.13 g / methanol; hexane / 20 °C
10.1: 84 percent / TFA / CH2Cl2 / 3 h / 0 °C
With
chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; water; acetone;
2.1: Dess-Martin oxidation / 6.1: Mitsunobu reaction / 8.1: Jones oxidation;
DOI:10.1021/jo034441n
