5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

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Chemical Name:5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester
CAS No.:710322-35-3
Molecular Formula:C₂₄H₃₀ClN₃O₅S
Molecular Weight:508.038
Hs Code.:

Synonyms:5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

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Chemical Property of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

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Technology Process of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

There total 3 articles about 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 300356-14-3
(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

: 710322-34-2
5-amino-pyrazine-2-carboxylic acid tert-butyl ester

: 710322-35-3
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

Guidance literature:: (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 1.25h;

5-amino-pyrazine-2-carboxylic acid tert-butyl ester; With pyridine; In tetrahydrofuran; dichloromethane; at 0 - 25 ℃;

Reference yield:

: 169335-50-6
5-chloropyrazine-2-carboxylic acid tert-butyl ester

: 710322-35-3
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver fluoride / acetonitrile / Inert atmosphere

1.2: Inert atmosphere

2.1: Inert atmosphere

With silver fluoride; In acetonitrile;
DOI:10.1021/ml400027y

Reference yield:

: 36070-80-1
5-chloropyrazinoic acid

: 710322-35-3
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; cyclohexane / 0.08 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: silver fluoride / acetonitrile / Inert atmosphere

2.2: Inert atmosphere

3.1: Inert atmosphere

With silver fluoride; In tetrahydrofuran; cyclohexane; acetonitrile;
DOI:10.1021/ml400027y