N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

• Chemical Name: N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS No.: 760190-09-8
• Molecular Formula: C₃₀H₃₀N₂O₇
• Molecular Weight: 530.577
• Mol file: 760190-09-8.mol

Synonyms:N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 4 articles about N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-(3,4-bis(benzyloxy)phenethylcarbamoyl) propanoic acid (300362-70-3) → N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester (760190-09-8)

Guidance literature:

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In chloroform; for 3h;

DOI:10.1021/ja0464802

Reference yield:

N-(tert-butoxycarbonyl)dopamine (37034-31-4) → N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester (760190-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

2: TFA / CH₂Cl₂ / 5 h / 20 °C

3: 94 percent / pyridine / 5 h / 20 °C

4: 80 percent / NHS; DMAP; DCC / CHCl₃ / 3 h

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja0464802

Reference yield:

3,4-di(benzyloxy)phenethylamine (55536-65-7) → N-[2-(3,4-bis-benzyloxyphenyl)ethyl]succinimic acid 2,5-dioxo-pyrrolidin-1-yl ester (760190-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / 5 h / 20 °C

2: 80 percent / NHS; DMAP; DCC / CHCl₃ / 3 h

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In chloroform;

DOI:10.1021/ja0464802

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3-(3,4-bis(benzyloxy)phenethylcarbamoyl) propanoic acid

N-(tert-butoxycarbonyl)dopamine

3,4-di(benzyloxy)phenethylamine

Downstream raw materials:

N-[2-(3,4-bis-benzyloxy-phenyl)-ethyl]-succinamic-L-phenylalanine

N-[2-(3,4-bis-benzyloxy-phenyl)-ethyl]-succinamic-L-phenylalanyl-L-phenylalanine

N⁽¹⁾-(3,4-bis(benzyloxy)phenethyl)-N⁽⁴⁾-((8-hydroxyquinolin-5-yl)methyl)succinamide