2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

Base Information

Chemical Name:2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
CAS No.:216665-66-6
Molecular Formula:C₁₉H₁₄ClF₆N₃O₅S
Molecular Weight:545.847
Hs Code.:

2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-<i>N</i>-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

Synonyms:2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

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Chemical Property of 2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

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Technology Process of 2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

There total 6 articles about 2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 393-11-3
4-nitro-3-(trifluoromethyl)benzeneamine

: 476314-49-5
2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

: 216665-66-6
2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: With thionyl chloride; In N,N-dimethyl acetamide; at -15 - 25 ℃; for 72h;
DOI:10.1016/S0223-5234(02)01335-1

Reference yield:

: 13113-79-6
sodium 4-nitrobenzenethiolate

: 216665-66-6
2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / tetrahydrofuran / 3 h / 0 - 25 °C

2: 67 percent / H₂SO₄ / H₂O / 20 h / 0 - 25 °C

3: 47 percent / conc. HCl / acetic acid / 24 h / Heating

4: tin(II) chloride dihydrate; conc. HCl / methanol / 24 h / 0 - 25 °C

5: 62 percent / CaCO₃ / acetonitrile / 48 h / 25 °C

6: 14 percent / thionyl chloride / N,N-dimethyl-acetamide / 72 h / -15 - 25 °C

With hydrogenchloride; thionyl chloride; sulfuric acid; calcium carbonate; tin(ll) chloride; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; acetic acid; acetonitrile;
DOI:10.1016/S0223-5234(02)01335-1

Reference yield:

: 90357-44-1
1,1,1-trifluoro-3-[(4-nitrophenyl)sulfanyl]acetone

: 216665-66-6
2-[4-(2-chloro-acetylamino)-phenylsulfanylmethyl]-3,3,3-trifluoro-2-hydroxy-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / H₂SO₄ / H₂O / 20 h / 0 - 25 °C

2: 47 percent / conc. HCl / acetic acid / 24 h / Heating

3: tin(II) chloride dihydrate; conc. HCl / methanol / 24 h / 0 - 25 °C

4: 62 percent / CaCO₃ / acetonitrile / 48 h / 25 °C

5: 14 percent / thionyl chloride / N,N-dimethyl-acetamide / 72 h / -15 - 25 °C

With hydrogenchloride; thionyl chloride; sulfuric acid; calcium carbonate; tin(ll) chloride; In methanol; N,N-dimethyl acetamide; water; acetic acid; acetonitrile;
DOI:10.1016/S0223-5234(02)01335-1