2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

Base Information

Chemical Name:2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid
CAS No.:476314-49-5
Molecular Formula:C₁₂H₁₁ClF₃NO₄S
Molecular Weight:357.738
Hs Code.:

Synonyms:2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

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Chemical Property of 2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

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Technology Process of 2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

There total 5 articles about 2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 79-04-9
chloroacetyl chloride

: 2-({[4-(amino)phenyl]sulfanyl}methyl)-3,3,3-trifluoro-2-hydroxypropanoic acid

: 476314-49-5
2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

Guidance literature:: With calcium carbonate; In acetonitrile; at 25 ℃; for 48h;
DOI:10.1016/S0223-5234(02)01335-1

Reference yield:

: 13113-79-6
sodium 4-nitrobenzenethiolate

: 476314-49-5
2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / tetrahydrofuran / 3 h / 0 - 25 °C

2: 67 percent / H₂SO₄ / H₂O / 20 h / 0 - 25 °C

3: 47 percent / conc. HCl / acetic acid / 24 h / Heating

4: tin(II) chloride dihydrate; conc. HCl / methanol / 24 h / 0 - 25 °C

5: 62 percent / CaCO₃ / acetonitrile / 48 h / 25 °C

With hydrogenchloride; sulfuric acid; calcium carbonate; tin(ll) chloride; In tetrahydrofuran; methanol; water; acetic acid; acetonitrile;
DOI:10.1016/S0223-5234(02)01335-1

Reference yield:

: 90357-44-1
1,1,1-trifluoro-3-[(4-nitrophenyl)sulfanyl]acetone

: 476314-49-5
2-[({4-[(2-chloroacetyl)amino]phenyl}sulfanyl)methyl]-3,3,3-trifluoro-2-hydroxypropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / H₂SO₄ / H₂O / 20 h / 0 - 25 °C

2: 47 percent / conc. HCl / acetic acid / 24 h / Heating

3: tin(II) chloride dihydrate; conc. HCl / methanol / 24 h / 0 - 25 °C

4: 62 percent / CaCO₃ / acetonitrile / 48 h / 25 °C

With hydrogenchloride; sulfuric acid; calcium carbonate; tin(ll) chloride; In methanol; water; acetic acid; acetonitrile;
DOI:10.1016/S0223-5234(02)01335-1