2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

Base Information

Chemical Name:2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide
CAS No.:870615-91-1
Molecular Formula:C₂₂H₂₅Cl₂N₃O₅
Molecular Weight:482.364
Hs Code.:

Synonyms:2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

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Chemical Property of 2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

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Technology Process of 2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

There total 2 articles about 2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 134420-06-7
p-ethoxy phenyl isonitrile

: 78-81-9
isobutylamine

: 79-11-8
chloroacetic acid

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

: 870615-91-1
2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

Guidance literature:: In methanol; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2005.09.071

Reference yield:

: 156-43-4
4-Ethoxyaniline

: 870615-91-1
2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / aq. sodium hydroxide; triethylbenzylammonium chloride / CH₂Cl₂ / 2 h

2: 89 percent / methanol / 24 h / 20 °C

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In methanol; dichloromethane; 2: Ugi reaction;
DOI:10.1016/j.tetlet.2005.09.071

Reference yield:

: 870615-91-1
2-(N-chloroacetyl-N-isobutyl)amino-2-(2-chloro-5-nitro)phenylacetic acid N-(4-ethoxy)phenyl amide

: 4-isobutyl-7-nitro-3-oxo-2,3,4,5-tetrahydrobenzo[1,4]thiazepin-5-carboxylic acid N-(4-ethoxyphenyl) amide

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 12 h / 20 °C

2: aq. KOH / ethanol / 2 h / Heating

With potassium hydroxide; In ethanol; acetone;
DOI:10.1016/j.tetlet.2005.09.071