(S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

• Chemical Name: (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
• CAS No.: 168104-53-8
• Molecular Formula: C₃₂H₃₈O₆S
• Molecular Weight: 550.716
• Mol file: 168104-53-8.mol

Synonyms:(S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property of (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 3 articles about (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanesulfonyl chloride (124-63-0) + (S)-Hydroxy-(4-hydroxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (168104-52-7) → (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (168104-53-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm00010a016

Reference yield:

Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester (88002-15-7) → (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (168104-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) aq. concd HF / 1.) THF, from -78 deg C to RT, overnight, 2.) CH₃CN, 1 h

2: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With hydrogen fluoride; triethylamine; In dichloromethane;

DOI:10.1021/jm00010a016

Reference yield:

<4-<<(tert-butyldimethylsilyl)oxy>methyl>phenyl>magnesium bromide (107556-40-1) → (S)-Hydroxy-(4-methanesulfonyloxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (168104-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) aq. concd HF / 1.) THF, from -78 deg C to RT, overnight, 2.) CH₃CN, 1 h

2: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With hydrogen fluoride; triethylamine; In dichloromethane;

DOI:10.1021/jm00010a016

upstream raw materials:

methanesulfonyl chloride

(S)-Hydroxy-(4-hydroxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester

<4-<<(tert-butyldimethylsilyl)oxy>methyl>phenyl>magnesium bromide

Downstream raw materials:

(S)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetic acid

(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (S)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetate