2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Base Information

Chemical Name:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate
CAS No.:1264294-83-8
Molecular Formula:C₂₃H₂₂ClN₃O₃S
Molecular Weight:455.965
Hs Code.:

Synonyms:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Suppliers and Price of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

There total 10 articles about 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264296-02-7
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropan-1-ol

: 124-63-0
methanesulfonyl chloride

: 1264294-83-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1264294-83-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 55 °C

2.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

3.1: hydrogenchloride / water

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

4.2: 0 °C

5.1: hydrogenchloride; water / acetone / 1 h

6.1: dmap; triethylamine / dichloromethane / 2 h

7.1: 16 h / 125 °C

8.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

9.1: sodium methylate / methanol / 1.5 h

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

With hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;

Reference yield:

: 1264295-94-4
ethyl2-methyl-2-(2-methyl-1,3-dioxolan-2-yl)-3-phenylpropanoate

: 1264294-83-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

2.1: hydrogenchloride / water

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

3.2: 0 °C

4.1: hydrogenchloride; water / acetone / 1 h

5.1: dmap; triethylamine / dichloromethane / 2 h

6.1: 16 h / 125 °C

7.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

8.1: sodium methylate / methanol / 1.5 h

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

With hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;