3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

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Chemical Name:3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine
CAS No.:1264294-84-9
Molecular Formula:C₂₅H₂₂ClN₅
Molecular Weight:427.936
Hs Code.:

Synonyms:3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

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Chemical Property of 3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

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Technology Process of 3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

There total 11 articles about 3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264294-83-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropyl methanesulfonate

: 40958-82-5
sodium pyrazolide

: 1264294-84-9
3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: In dimethyl sulfoxide; at 110 ℃; for 1.5h;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1264294-84-9
3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 55 °C

2.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

3.1: hydrogenchloride / water

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

4.2: 0 °C

5.1: hydrogenchloride; water / acetone / 1 h

6.1: dmap; triethylamine / dichloromethane / 2 h

7.1: 16 h / 125 °C

8.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

9.1: sodium methylate / methanol / 1.5 h

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

11.1: dimethyl sulfoxide / 1.5 h / 110 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; dimethyl sulfoxide; acetone;

Reference yield:

: 1264295-97-7
2-methyl-2-(2-methyl-1,3-dioxolan-2-yl)-3-phenylpropan-1-ol

: 1264294-84-9
3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; water / acetone / 1 h

2: dmap; triethylamine / dichloromethane / 2 h

3: 16 h / 125 °C

4: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

5: sodium methylate / methanol / 1.5 h

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

7: dimethyl sulfoxide / 1.5 h / 110 °C

With hydrogenchloride; dmap; water; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; acetone;