methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Base Information

Chemical Name:methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate
CAS No.:1210048-33-1
Molecular Formula:C₂₇H₂₂FN₅O₂
Molecular Weight:467.502
Hs Code.:

Synonyms:methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

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Chemical Property of methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

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Technology Process of methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

There total 1 articles about methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1210048-32-0
7-bromo-5-fluoroquinazoline

: 1209485-74-4
methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

: 73183-34-3
bis(pinacol)diborane

: 1210048-33-1
methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Guidance literature:: 7-bromo-5-fluoroquinazoline; bis(pinacol)diborane; With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 110 ℃; Inert atmosphere;

methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate; With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

Reference yield: 99.0%

: 1210048-33-1
methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

: 1210049-04-9
2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzoic acid

Guidance literature:: methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In water;