7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine

Base Information

• Chemical Name: 7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine
• CAS No.: 1295571-12-8
• Molecular Formula: C₁₃H₁₀Cl₂N₄O
• Molecular Weight: 309.155

Synonyms:7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine

Chemical Property of 7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine

Chemical Property:

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Technology Process of 7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine

There total 2 articles about 7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine (938158-19-1) + 4-chloro-benzoyl chloride (122-01-0) → 7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine (1295571-12-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; Reflux;

DOI:10.1002/jhet.509 DOI:10.1515/HC.2011.009

Reference yield:

5-bromo-2,4-dichloro-6-methylpyrimidine (56745-01-8) → 7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine (1295571-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform

2: potassium carbonate / acetonitrile / 20 °C / Reflux

With potassium carbonate; In chloroform; acetonitrile;

DOI:10.1002/jhet.509 DOI:10.1515/HC.2011.009

Reference yield: 72.0%

7-chloro-3-(4-chlorophenyl)-1,5-dimethyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine (1295571-12-8) → 3-(4-chlorophenyl)-1,5-dimethyl-7-hydrazino-1H-pyrimido[4,5-e][1,3,4]oxadiazine (1295571-14-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1002/jhet.509

upstream raw materials:

1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine

4-chloro-benzoyl chloride

5-bromo-2,4-dichloro-6-methylpyrimidine

Downstream raw materials:

C₁₄H₁₁ClN₆O

C₁₅H₁₃ClN₆O

3-(4-chlorophenyl)-1,5-dimethyl-7-hydrazino-1H-pyrimido[4,5-e][1,3,4]oxadiazine

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