N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

Base Information

Chemical Name:N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide
CAS No.:229017-35-0
Molecular Formula:C₄₃H₃₈NO₆P
Molecular Weight:695.752
Hs Code.:

Synonyms:N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

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Technology Process of N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

There total 6 articles about N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 122365-23-5
N-[(diphenylphosphinoyl)methyl]-N-methylamine

: 229017-42-9
2-(4-Benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzoic acid

: 229017-35-0
N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1039/a809925a

Reference yield:

: 1486-51-7
p-(benzyloxy)benzoic acid

: 229017-35-0
N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / Ph₃P, DEAD / tetrahydrofuran / 0.67 h / 25 °C

2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C

3: NMO, 3 Angstroem molecular sieves, TPAP / acetonitrile / 0.5 h / 25 °C

4: 89 percent / 2-methylbut-2-ene, NaClO₂, H₂O, Na₂HPO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 8 h / 25 °C

5: 82 percent / DCC, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; sodium chlorite; disodium hydrogenphosphate; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 3 A molecular sieve; water; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1039/a809925a

Reference yield:

: 38849-39-7
3-benzyloxy-2-bromo-4-methoxybenzyl alcohol

: 229017-35-0
N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / Ph₃P, DEAD / tetrahydrofuran / 0.67 h / 25 °C

2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C

3: NMO, 3 Angstroem molecular sieves, TPAP / acetonitrile / 0.5 h / 25 °C

4: 89 percent / 2-methylbut-2-ene, NaClO₂, H₂O, Na₂HPO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 8 h / 25 °C

5: 82 percent / DCC, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; sodium chlorite; disodium hydrogenphosphate; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 3 A molecular sieve; water; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1039/a809925a