1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Base Information

• Chemical Name: 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone
• CAS No.: 445290-49-3
• Molecular Formula: C₃₁H₃₂N₂O₄
• Molecular Weight: 496.606
• Mol file: 445290-49-3.mol

Synonyms:1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Chemical Property of 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone

There total 4 articles about 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone (401792-02-7) + N-[2-(2-benzyloxyphenyl)-ethylcarboxy]succinimide (445290-40-4) → 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone (445290-49-3)

Guidance literature:

In dichloromethane;

DOI:10.1211/0022357021778592

Reference yield:

3-(2'-(Benzyloxy)phenyl)propionic Acid (48179-00-6) → 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone (445290-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 4-dimethylaminopyridine; dicyclohexyldicarbodiimide / CH₂Cl₂

2: 90 percent / CH₂Cl₂

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1211/0022357021778592

Reference yield:

benzyl bromide (100-39-0) → 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone (445290-49-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / NaOH / H₂O; methanol

2: 90 percent / KOH; H₂O / tetrahydrofuran / 4 h / Heating

3: 94 percent / 4-dimethylaminopyridine; dicyclohexyldicarbodiimide / CH₂Cl₂

4: 90 percent / CH₂Cl₂

With dmap; potassium hydroxide; sodium hydroxide; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1211/0022357021778592

upstream raw materials:

2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone

N-[2-(2-benzyloxyphenyl)-ethylcarboxy]succinimide

3-(2'-(Benzyloxy)phenyl)propionic Acid

benzyl bromide