Technology Process of 4-Cyanophenyl cyclopentyl ketone
There total 3 articles about 4-Cyanophenyl cyclopentyl ketone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromobenzenecarbonitrile;
With
isopropylmagnesium bromide;
In
tetrahydrofuran;
at -30 ℃;
for 0.5h;
Inert atmosphere;
N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine;
In
tetrahydrofuran;
at -30 - 30 ℃;
for 16h;
- Guidance literature:
-
4-bromobenzenecarbonitrile;
With
TurboGrignard;
In
tetrahydrofuran;
at -20 ℃;
Cyclopentanecarboxylic acid chloride;
With
copper(I) cyanide di(lithium chloride);
In
tetrahydrofuran;
at -20 ℃;
for 2h;
DOI:10.1002/anie.201006966
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 28 °C
1.2: 16 h / 28 °C
2.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere
2.2: 16 h / -30 - 30 °C
With
isopropylmagnesium bromide; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; dichloromethane;
