(1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:(1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1430746-07-8
Molecular Formula:C₂₅H₃₁NO₄
Molecular Weight:409.525
Hs Code.:

Synonyms:(1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of (1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 1 articles about (1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

: 103-16-2
4-Benzyloxyphenol

: 143557-91-9
(1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430746-07-8
(1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Cooling with ice;

Reference yield: 99.0%

: 1430746-07-8
(1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430746-08-9
(1R,3s,5S)-tert-butyl 3-(4-hydroxyphenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 3h; under 1140.08 Torr;

Reference yield:

: 1430746-07-8
(1R,3s,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430745-44-0
(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(4-bromo-2-cyanophenoxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C / 1140.08 Torr

2: sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 24 h / 80 °C / 9000.9 Torr / Autoclave

3: di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With sodium tetraborate decahydrate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; isopropyl alcohol;