tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate
• CAS No.: 1059145-60-6
• Molecular Formula: C₃₀H₃₉N₇O₄
• Molecular Weight: 561.684
• Mol file: 1059145-60-6.mol

Synonyms:tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate

Chemical Property of tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate

There total 5 articles about tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone (1059145-57-1) + N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) → tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate (1059145-60-6)

Guidance literature:

N-(tert-butoxycarbonyl)-4-aminobutanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone; In N,N-dimethyl-formamide; at 20 ℃; for 66h;

Reference yield:

benzyl 2-(4-(aminomethyl)benzoyl)pyrazolidine-1-carboxylate (1059147-36-2) → tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate (1059145-60-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol / 1.5 h / 50 °C

1.2: 1 h / 0 °C

2.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 17 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 66 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; acetic acid; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate (1059147-35-1) → tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate (1059145-60-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.1: methanol / 1.5 h / 50 °C

2.2: 1 h / 0 °C

3.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 17 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

5.2: 66 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; acetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone

N-(tert-butoxycarbonyl)-4-aminobutanoic acid

benzyl 2-(4-(aminomethyl)benzoyl)pyrazolidine-1-carboxylate

benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate