benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate

Base Information

• Chemical Name: benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate
• CAS No.: 1059147-35-1
• Molecular Formula: C₂₄H₂₉N₃O₅
• Molecular Weight: 439.511
• Mol file: 1059147-35-1.mol

Synonyms:benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate

Chemical Property of benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate

There total 2 articles about benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-Butoxycarbonylaminomethyl)benzoic acid (33233-67-9) + benzyl pyrazolidine-1-carboxylate hydrochloride (57699-90-8) → benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate (1059147-35-1)

Guidance literature:

4-(tert-Butoxycarbonylaminomethyl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

benzyl pyrazolidine-1-carboxylate hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

Reference yield:

1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine (57699-88-4) → benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate (1059147-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 17 h / 20 °C

2.1: thionyl chloride / methanol / 16 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 18 h / 0 - 20 °C

With thionyl chloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate (1059147-35-1) → benzyl 2-(4-(aminomethyl)benzoyl)pyrazolidine-1-carboxylate (1059147-36-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

upstream raw materials:

4-(tert-Butoxycarbonylaminomethyl)benzoic acid

benzyl pyrazolidine-1-carboxylate hydrochloride

1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

Downstream raw materials:

benzyl 2-(4-(aminomethyl)benzoyl)pyrazolidine-1-carboxylate

(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone

N-(4-(pyrazolidine-1-carbonyl)benzyl)-N-(pyridin-2-ylmethyl)benzenesulfonamide

benzyl 2-(4-((pyridin-2-ylmethylamino)methyl)benzoyl)-pyrazolidine-1-carboxylate