(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone

Base Information

• Chemical Name: (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone
• CAS No.: 1059145-57-1
• Molecular Formula: C₂₁H₂₄N₆O
• Molecular Weight: 376.461
• Mol file: 1059145-57-1.mol

Synonyms:(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone

Chemical Property of (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone

There total 4 articles about (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidine-1-carboxylate (1059145-55-9) → (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone (1059145-57-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 17h;

Reference yield:

benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate (1059147-35-1) → (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone (1059145-57-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.1: methanol / 1.5 h / 50 °C

2.2: 1 h / 0 °C

3.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 17 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h

With hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; palladium 10% on activated carbon; acetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

benzyl 2-(4-((pyridin-2-ylmethylamino)methyl)benzoyl)-pyrazolidine-1-carboxylate (1059147-38-4) → (4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)-methyl)phenyl)-(pyrazolidin-1-yl)methanone (1059145-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 17 h / 60 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 17 h

With hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; acetic acid; In methanol; 1,2-dichloro-ethane;

upstream raw materials:

benzyl 2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidine-1-carboxylate

benzyl 2-(4-(aminomethyl)benzoyl)pyrazolidine-1-carboxylate

benzyl 2-(4-((tert-butoxycarbonyl)methyl)benzoyl)-pyrazolidine-1-carboxylate

benzyl 2-(4-((pyridin-2-ylmethylamino)methyl)benzoyl)-pyrazolidine-1-carboxylate

Downstream raw materials:

tert-butyl 4-(2-(4-((((1H-imidazol-2-yl)methyl)(pyridin-2-ylmethyl)amino)methyl)benzoyl)pyrazolidin-1-yl)-4-oxobutylcarbamate