(3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Base Information

Chemical Name:(3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone
CAS No.:105318-32-9
Molecular Formula:C₂₆H₃₂N₂O₇SSi
Molecular Weight:544.701
Hs Code.:

Synonyms:(3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Suppliers and Price of (3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

There total 10 articles about (3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 75-77-4
chloro-trimethyl-silane

: 105318-30-7
(3S,4S)-3-<(1R)-1-hydroxyethyl>-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-2-azetidinone

: 105318-32-9
(3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Guidance literature:: With triethylamine; In toluene; for 5h; Ambient temperature;
DOI:10.1248/cpb.42.1381

Reference yield:

: 93711-85-4,97101-07-0,113033-46-8,120710-59-0,120710-60-3,90776-58-2
(2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid

: 105318-32-9
(3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / K₂CO₃ / acetone / 4 h / Heating

2: 100 percent / NaH / tetrahydrofuran / 2 h / 0 °C

3: 100 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h

5: CH₂Cl₂ / 1 h

6: 86 percent / anisole, TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

7: 93 percent / γ-collidine / dimethylformamide / 1.5 h / 65 °C

8: 98 percent / Et₃N / toluene / 5 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; hydrogen; titanium tetrachloride; sodium hydride; potassium carbonate; methoxybenzene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1248/cpb.42.1381

Reference yield:

: 96035-98-2
(3S,4S)-4-<(1R)-1-benzyloxycarbonylethyl>-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>-2-azetidinone

: 105318-32-9
(3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / NaH / tetrahydrofuran / 2 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h

4: CH₂Cl₂ / 1 h

5: 86 percent / anisole, TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

6: 93 percent / γ-collidine / dimethylformamide / 1.5 h / 65 °C

7: 98 percent / Et₃N / toluene / 5 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; hydrogen; titanium tetrachloride; sodium hydride; methoxybenzene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.42.1381