(+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Base Information

Chemical Name:(+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran
CAS No.:134456-11-4
Molecular Formula:C₂₂H₂₉N₃O₃
Molecular Weight:383.491
Hs Code.:

Synonyms:(+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

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Chemical Property of (+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

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Technology Process of (+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

There total 4 articles about (+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 134456-08-9
cis-1-(bromomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

: 134456-11-4
(+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Guidance literature:: With lithium azide; In N,N-dimethyl-formamide; at 70 ℃; for 3h;
DOI:10.1021/jm00112a034

Reference yield:

: 3483-39-4
Cyclohexyloxirane

: 134456-11-4
(+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) hexane, THF, RT, 4 h, 2.) hexane, THF, from 0 deg C to RT, 2 h

2: 77 percent / BF₃OEt₂ / diethyl ether / 24 h / Ambient temperature

3: 75 percent / LiN₃ / dimethylformamide / 3 h / 70 °C

With n-butyllithium; lithium azide; boron trifluoride diethyl etherate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a034

Reference yield:

: 134456-07-8
2-cyclohexyl-1-spiro<1,3-benzodioxole-2,1'-cyclohexane>-2-ethanol

: 134456-11-4
(+/-)-1-(azidomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / BF₃OEt₂ / diethyl ether / 24 h / Ambient temperature

2: 75 percent / LiN₃ / dimethylformamide / 3 h / 70 °C

With lithium azide; boron trifluoride diethyl etherate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a034