4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

Base Information

Chemical Name:4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide
CAS No.:1426095-85-3
Molecular Formula:C₁₈H₂₃BrN₂O₂
Molecular Weight:379.297
Hs Code.:

Synonyms:4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

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Chemical Property of 4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

Chemical Property:

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Technology Process of 4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

There total 7 articles about 4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-84-2
4-bromo-N-ethyl-N-[(3R)-3-pyrrolidinylmethyl]benzamide hydrochloride

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1426095-85-3
4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1426095-85-3
4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / methanol / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 1366767-71-6
1,1-dimethylethyl (3S)-3-({[(4-bromophenyl)carbonyl]amino}methyl)-1-pyrrolidinecarboxylate

: 1426095-85-3
4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / methanol / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;