3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

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Chemical Name:3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide
CAS No.:1426095-22-8
Molecular Formula:C₂₄H₂₆ClFN₂O₂
Molecular Weight:428.934
Hs Code.:

Synonyms:3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

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Chemical Property of 3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

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Technology Process of 3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

There total 8 articles about 3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-85-3
4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethylbenzamide

: 144432-85-9
3-chloro-4-fluorophenylboronic acid

: 1426095-22-8
3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1426095-22-8
3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / methanol / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;

Reference yield:

: 1366767-71-6
1,1-dimethylethyl (3S)-3-({[(4-bromophenyl)carbonyl]amino}methyl)-1-pyrrolidinecarboxylate

: 1426095-22-8
3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4'-fluoro-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / methanol / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;